张计敏
职称:讲师,硕士生导师
教育背景:
2015.09-2018.06,南开大学,生物化学分子生物学,博士
2009.09-2012.06,南开大学,药物化学,硕士
2005.09-2009.06,青岛科技大学,应用化学,本科
工作履历:
2018.10-至今,化工学院,讲师、硕导
学术任职:
中国生物材料学会会员
研究领域与承担项目:
研究领域:
1.生物医用高分子材料
2.刺激响应高分子材料
3.智能传感功能材料
基金和项目:
1.国家自然科学基金,青年项目,2024-2026,主持
2.河北省自然科学基金,青年项目,2020-2022,主持
3.河北省高等学校科学技术基金,青年项目,2022-2024,主持
4.南开大学、中国医科院医工所,开放课题,2022-2024,主持
5.国家自然科学基金,联合基金重点项目,2021-2024,参与
6.本科教育教学改革研究项目,2024-2025,主持
奖励与荣誉:
元光学者启航岗B,天津市课程思政教学名师,国家奖学金研究生指导教师,优秀毕设指导教师,本科教学质量优秀教师,化工学院2023年科技工作先进个人
代表性著作:
[1] Peng Zhao, Yu Zhang, Xiaoai Chen, Chang Xu, Jingzhe Guo, Meigui Deng, Xiongwei Qu, Pingsheng Huang*, Zujian Feng*, Jimin Zhang*. Versatile Hydrogel Dressing with Skin Adaptiveness and Mild Photothermal Antibacterial Activity for Methicillin-Resistant Staphylococcus Aureus-Infected Dynamic Wound Healing, Advanced Science, 2023, 2206585. (IF= 17.521)
[2] Xiaoai Chen, Chang Xu, Peng Zhao, Yu Zhang, Jingzhe Guo, Xiuli Hu, Hui Gao, Chuangnian Zhang*, Xiongwei Qu*, Jimin Zhang*. A multichannel Ca2+ nanomodulator amplifies exogenous and endogenous calcium overload for efficient antitumor and antimetastasis therapy, Chemical Engineering Journal, 2023, 142478. (IF= 16.744)
[3] Jimin Zhang, Meigui Deng, Xiaoguang Shi, Chuangnian Zhang, Xiongwei Qu, Xiuli Hu*, Weiwei Wang*, Deling Kong, Pingsheng Huang*. Cascaded amplification of intracellular oxidative stress and reversion of multidrug resistance by nitric oxide prodrug based-supramolecular hydrogel for synergistic cancer chemotherapy[J]. Bioactive Materials, 2021, 6(10): 3300-3313. (IF= 18.9)
[4] Yu Zhang, Peng Zhao, Xiaoai Chen, Chang Xu, Jingzhe Guo, Xiongwei Qu, Xiuli Hu, Hui Gao, Pingsheng Huang*, Jimin Zhang*, et al. Near Infrared-Activatable Methylene Blue Polypeptide Codelivery of the NO Prodrug via π−π Stacking for Cascade Reactive Oxygen 3 Species Amplification-Mediated Photodynamic Therapy, ACS Applied Materials & Interfaces, 2023, 15: 12750-12765. (IF= 10.383)
[5] Jimin Zhang, Huijuan Song, Shenglu Ji, Xiaomin Wang, Pingsheng Huang, Chuangnian Zhang, Weiwei Wang*, Deling Kong*. NO prodrug-conjugated, self-assembled, pH-responsive and galactose receptor targeted nanoparticles for co-delivery of nitric oxide and doxorubicin. Nanoscale, 2018, 10, 4179-4188. (IF= 8.307)
[6] Jimin Zhang, Jianing Wang, Yongzhen Wei, Cheng Gao, Xuejiao Chen, Wei Kong, Deling Kong*, Qiang Zhao*. ECM-mimetic heparin glycosamioglycan-functionalized surface favors constructing functional vascular smooth muscle tissue in vitro. Colloids and Surfaces B: Biointerfaces, 2016, 146: 280-288. (IF= 6.0)
[7] Chunyong Liang, Jiying Song, Yongguang Zhang, Yaping Guo, Meigui Deng, Wei Gao*, Jimin Zhang*. Facile Approach to Prepare rGO@Fe3O4 Microspheres for the Magnetically Targeted and NIR-responsive Chemo-photothermal Combination Therapy. Nanoscale Research Letters, 2020, 15(86): 1-11. (IF= 5.418)
[8] Peiqiong Zhao, Meigui Deng, Yongfang Yang*, Jimin Zhang*, Yue Zhang*. Synthesis and Self-Assembly of Thermoresponsive Biohybrid Graft Copolymers Based on a Combination of Passerini Multicomponent Reaction and Molecular Recognition[J]. Macromolecular Rapid Communications, 2021, 42(21): 2100424. (IF= 5.006)
[9] Yue Zhang*, Rong Zhao, Yan Qin, Jianguo Yi, Jimin Zhang*, Xiaoai Chen. Synthesis and self-assembly of hyperbranched multiarm copolymer peptide conjugates based on light-induced metal-free ATRP[J]. Polym. Chem., 2023, 14, 2930-2939. (IF= 4.6)
[10] 廖日鑫, 李国华, 张计敏*, 胡秀丽, 瞿雄伟. 聚氨基酸在肿瘤免疫治疗中的应用, 高分子材料科学与工程, 2021, 37(8): 182-190. (EI)
专利申请与授权情况:
1. 张计敏,赵鹏,邓梅桂,陈小爱,张宇,瞿雄伟. 一种多功能抗菌水凝胶敷料的制备方法及应用,ZL 202111312519.X. 授权专利
2. 张计敏,邓梅桂,赵鹏,张宇,陈小爱. 一种用于级联递送药物的透明质酸纳米给药系统的制备方法,ZL202211307057.7. 授权专利
3. 张计敏,邓梅桂,赵鹏,张宇,陈小爱,徐畅,郭靖喆,瞿雄伟. 一种光敏剂和一氧化氮前药的给药系统其及制备方法,CN115804849A. 公开专利
4. 张计敏,陈小爱,张宇,赵鹏,徐畅,郭靖喆,瞿雄伟. 一种多通道促肿瘤钙超载的Ca2+纳米调节剂制备方法,CN116440078A. 公开专利
5. 张计敏,张宇,赵鹏,陈小爱,徐畅,郭靖喆,瞿雄伟.一种一氧化氮与顺铂共递送纳米粒子及其制备和应用,CN116492314A. 公开专利
6. 张计敏,张宇,陈小爱,赵鹏,徐畅,郭靖喆,瞿雄伟. 一种NIR活化的亚甲基蓝聚氨基酸共递送一氧化氮的级联放大光动力的应用系统,2023100836135.